T4 circulates through to the liver where 60% of it is converted into T3 through the glucoronination and sulfation pathways. If the liver is sluggish it will cause a problem in T4-T3 conversion (6). Another 20% is converted into reverse T3 which is permanentely inactive. The final 20% is converted into T3 sulfate and T3 acetic acid which can then be further metabolized by healthy gut bacteria to produce more active T3 (6).
The development of TSH assays led to a dramatic reduction in thyroid hormone replacement dosage and the ability to diagnose with certainty milder forms of hypothyroidism. Discovery of peripheral T4-to-T3 conversion gave a physiologic means to justify l-thyroxine monotherapy. In combination with the concerns over consistency and safety of natural thyroid preparations, synthetic l-thyroxine was perceived as a more reliable therapy. These findings laid the foundation for the clinical practice trend away from natural thyroid preparations and toward l-thyroxine monotherapy at doses to normalize the serum TSH. Later, a subpopulation of patients with residual symptoms of hypothyroidism was recognized. It remains to be determined whether this is due to a trend of attributing nonspecific symptoms to minimal thyroid dysfunction, relatively low serum T3 levels and/or high T4:T3 ratio, or the role of Thr92AlaD2 polymorphism, and whether combination therapy with l-thyroxine plus l-triiodothyronine will be beneficial.
Traditional Chinese Medicine: Although not well studied in addressing hypothyroidism, TCM can have positive effects on imbalances in the immune system, and is useful in treating other autoimmune conditions. It may be helpful early in the course of Hashimoto’s, but TCM should not be used in place of conventional therapy when thyroid replacement is indicated.
Dr. Josh Axe is a certified doctor of natural medicine, doctor of chiropractic, and clinical nutritionist with a passion to help people get healthy by using food as medicine. Dr. Axe has created one of the top 10 most visited natural health websites in the world at www.DrAxe.com which has over 15 million monthly visitors. Dr. Axe has been a physician for many professional athletes. In 2009, he began working with the Wellness Advisory Council and Professional Swim Teams. He worked with professional swimmers, including Ryan Lochte and Peter Vanderkaay, providing nutritional advice and musculoskeletal work on the athletes to increase their performance. He also traveled to the 2012 Games in London to work with USA athletes. Dr. Axe has authored several books including his new book Eat Dirt: Why Leaky Gut May Be the Root Cause of Your Health Problems and 5 Surprising Steps to Cure It.
The problematic compound in soy (for your thyroid) are the isoflavones. In fact, a study in the Journal of Clinical Endocrinology and Metabolism reported that researchers fed some subjects 16 mg of soy isoflavones, which is the amount found in the typical vegetarian's diet, and others 2 mg soy isoflavones, which is the amount found in most omnivore's diets.
This can lead to low T3 levels (58). In addition, elevated cortisol will cause thyroid hormone receptor insensitivity meaning that even if T3 levels are high enough, they may not be able to bind normally to receptor sites. And when this happens it doesn’t get into the cells. Cortisol will also increase the production of reverse T3 (rT3), which is inactive (11).
In the developed world, where protein is plentiful and many countries add iodine to salt and processed foods, we don’t typically need to worry about protein malnutrition or iodine deficiency. However, the rest of the world is not so lucky. More than 2 billion people around the world suffer from hypothyroidism due to iodine deficiency. 2 billion! We are told that the reason for this planetary epidemic is that iodine comes from the ocean, and that the soil of inland areas has had most of its iodine washed away over time by erosion:
Refined Flour Products – Any food made with refined carbohydrates, like enriched wheat flour, for example, negatively impacts hormone levels and can contribute to weight gain. Refined flour products include bread, cereals, pastas and all baked goods. If possible, remove most grains from your diet all together, or at least try to greatly limit the amount of products you eat that are made with any flour by choosing 100 percent whole, ancient grains instead (like quinoa, buckwheat, etc.)
Thyroid hormones regulate cholesterol synthesis, cholesterol receptors, and the rate of cholesterol degradation. Hypothyroidism increases LDL levels, and increased cholesterol levels have been shown to induce hypothyroidism in animal models. Normalization of thyroid hormone levels has a beneficial effect on cholesterol, which may be worth noting especially for clients who choose not to take prescribed thyroid medications.7
To document that this was a result of trends toward lower doses, an unblinded study tracked well-being according to various doses and found that the highest well-being was achieved at supraoptimal doses, resulting in a suppressed TSH (65). However, a blinded trial did not reproduce this finding (66). In a call to the public, a 1997 British Thyroid Foundation newsletter asked readers to recount personal history of residual hypothyroid symptoms. More than 200 patients responded, 54 of whom specifically mentioned that they did not feel well despite normal serum markers of thyroid function (67, 68). Because of this surge in symptomatic patients, some clinicians advocated titrating dose by symptoms rather than serum TSH, reminiscent of the period before the 1970s (69).
Trisha Gilkerson is a homeschooling mom to four crazy boys. She blogs with her awesome hubby Luke at Intoxicated on Life where they talk about faith, homeschooling, and health. They’ve authored the Write Through the Bible curriculum and family Bible Studies and have recently released their first healthy living book – Weeding Out Wheat: A Simple Faith Based Guide. They love connecting with their readers, so be sure to follow them on their blog, Facebook, Twitter, Google+, and Pinterest.
Alcohol consumption can wreak havoc on both thyroid hormone levels in the body and the ability of the thyroid to produce hormone. Alcohol appears to have a toxic effect on the thyroid gland and suppresses the ability of the body to use thyroid hormone. Ideally, people with hypothyroidism should cut out alcohol completely or drink in careful moderation.
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