An amino acid used in the synthesis of thyroid hormones. Thyroxin (T4) is naturally produced from the iodination of tyrosine, a nonessential amino acid obtained both from protein-containing dietary sources and through the body making some itself. Supplementing with L-tyrosine has been shown to improve sleep deprivation and can help combat fatigue and a poor mood by improving alertness and neurotransmitter function. One reason L-tyrosine is beneficial in healing thyroid symptoms is because it plays a role in the production of melatonin, dopamine and/or norepinephrine, which are our natural “feel good” hormones. L-tyrosine is available by the brand Pure Encapsulations.
Initial strategies for thyroid hormone replacement included thyroid transplantation, but efficacious pharmacologic strategies soon won favor. Natural thyroid preparations containing T4 and T3, such as desiccated thyroid, thyroid extracts, or thyroglobulin, were the initial pharmacologic agents. Synthetic agents were synthesized later. Early clinical trials demonstrated the efficacy of synthetic and natural agents, but concerns arose regarding consistency of natural thyroid preparations and adverse effects associated with T3-containing preparations (natural or synthetic). With the demonstration of peripheral T4-to-T3 conversion and the availability of the serum TSH radioimmunoassay in the early 1970s, there was a major trend in prescribing preference toward l-thyroxine monotherapy. BMR = basal metabolic rate; DT = desiccated thyroid; IV = intravenous; RIA = radioim-munoassay; T3 = triiodothyronine; T4 = thyroxine; TG = thyroglobulin; TSH = thyroid-stimulating hormone.
Hypothyroidism (overactive thyroid) is a condition in which the thyroid gland produces an abnormally low amount of thyroid hormone. Many disorders result in hypothyroidism, which may directly or indirectly involve the thyroid gland. Because thyroid hormone affects growth, development, and many cellular processes, inadequate thyroid hormone has widespread consequences for the body.
Why does this happen? The immune system mistakenly thinks that the thyroid cells are not a part of the body, so it tries to remove them before they can cause damage and illness. The problem is that this causes widespread inflammation, which can result in many different problems. 90 percent of people with hypothyroidism have Hashimoto’s that inflames the thyroid gland over time, but this isn’t the only cause of hypothyroidism.
Less common causes of hypothyroidism include congenital (birth) defects (one of the reasons for newborn screening is to check for failure of the pituitary gland to produce enough thyroid stimulating hormone, usually due to a benign pituitary tumor), and pregnancy. Some women can develop hypothyroidism during or immediately following pregnancy, often as a result of developing antibodies against their own thyroid tissue. This is dangerous for both the developing fetus and mother, and can lead to miscarriage, developmental abnormalities, premature delivery and an increased risk of preeclampsia – a potentially dangerous complication in the later stages of pregnancy.
You may have read that green, leafy veggies like kale, bok choy, broccoli, and Brussels sprouts can make hypothyroidism worse. But before you keep reading, ask yourself a question: Do you live in the United States? That’s key — because if you do, you likely don’t need to worry about these cancer-fighting veggies messing with your hypothyroidism management. (7)
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