Toll-like receptors (TLRs) are an essential arm of the innate immune response to bacteria, viruses and fungi and link recognition of distinct features of these microbes to the induction of pro-inflammatory signaling pathways. These receptors are able to respond to broad classes of pathogens because each TLR recognizes specific conserved microbial features.
Although no one symptom qualifies someone as having lupus, certain clinical techniques can be used to narrow down the diagnosis. For example, a test for antinuclear antibodies (ANAs) in the blood is probably the first tool a physician will use. A positive ANA test does not necessarily mean that someone has lupus; in fact, one out of five normal women has a positive ANA. However, a negative ANA test greatly reduces the suspicion.
Often, people with lupus experience weight loss or gain due to loss of appetite, unhealthy dietary habits, or decreased energy and mobility. If you experience weight loss or loss of appetite, talk to your doctor. S/he can help you determine the cause of the problem and take strides to correct it. Weight gain can be caused by many factors, including reduced activity levels and overeating due to steroid use or increased stress. However, remember that women with lupus between the ages of 35 and 44 experience a risk of heat attack that is 50x that of the normal population. Therefore, it is very important that you try to stick to a diet that is low in cholesterol and saturated fats. A low-sodium diet is also essential for people suffering from high blood pressure (above 120/80 mmHg for people with lupus) and kidney disease.
Articular cartilage is the highly specialized connective tissue of diarthrodial joints. Its principal function is to provide a smooth, lubricated surface for articulation and to facilitate the transmission of loads with a low frictional coefficient. Articular cartilage is devoid of blood vessels, lymphatics, and nerves and is subject to a harsh biomechanical environment. Most important, articular cartilage has a limited capacity for intrinsic healing and repair. In this regard, the preservation and health of articular cartilage are paramount to joint health.
And it’s important to point out that people who are initially diagnosed with systemic lupus (or SLE) can also get lupus rashes. One of the common rashes that occurs in people with systemic lupus is malar rash. It’s alternatively called a butterfly rash, and it spreads across the bridge of the nose and cheeks and is telltale sign of the disease because its appearance is so distinctive, Caricchio says. A malar rash can be flat or raised. While it usually isn’t painful, it can itch and burn. (3) And the rash can show up on other parts of the body, including the arms, legs, and torso.
For instance, a dermatologist for cutaneous lupus (skin disease), a cardiologist for heart disease, a nephrologist for kidney disease, a neurologist for brain and nervous system disease, or a gastroenterologist for gastrointestinal tract disease. A woman with lupus who is considering a pregnancy needs an obstetrician who specializes in high-risk pregnancies.
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Please Note: The material on this site is provided for informational purposes only and is not medical advice. Always consult your physician before beginning any diet or exercise program.
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